Proto Oncogene Proteins c abl
《英文msh詞典》Proto Oncogene Proteins c abl
[入口詞] Proto Oncogene Proteins c abl
[主題詞] Proto-Oncogene Proteins c-abl
[英文釋義] Non-receptor tyrosine kinases encoded by the c-abl gene. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal hematopoiesis especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted,releasing the kinase from negative regulation.